ZFIN ID: ZDB-EXP-171219-9
Experiment Conditions Description: chemical treatment by environment: serotonin, chemical treatment by environment: oxidopamine, chemical treatment by environment: nepicastat
chemical treatment by environment: serotonin
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: serotonin
Synonyms: 3-(2-Aminoethyl)-1H-indol-5-ol, 5-HT, 5-Hydroxytryptamine, Enteramine, Serotonin, serotonine, thrombocytin, thrombotonin
Definition: A primary amino compound that is the 5-hydroxy derivative of tryptamine.
Ontology: ChEBI [CHEBI:28790]  ( EBI )
chemical treatment by environment: oxidopamine
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: oxidopamine
Synonyms: 2,4,5-trihydroxyphenethylamine, 5-(2-aminoethyl)benzene-1,2,4-triol, 6-hydroxydopamine, 6-OHDA, hydroxydopamine, oxidopamina, oxidopamine, oxidopaminum, topamine
Definition: A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Ontology: ChEBI [CHEBI:78741]  ( EBI )
chemical treatment by environment: nepicastat
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: nepicastat
Synonyms: (S)-5-aminomethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydroimidazole-2-thione, 5-(aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1,3-dihydro-2H-imidazole-2-thione, nepicastat, nepicastatum, RS-25560-197, SYN117
Definition: A member of the class of 1,3-dihydroimidazole-2-thiones that is 1,3-dihydro-2H-imidazole-2-thione in which one of the nitrogens is substituted by a 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl group while the carbon adjacent to it is substituted by an aminomethyl group (the S enantiomer). It is a potent and selective inhibitor of both bovine and human dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.
Ontology: ChEBI [CHEBI:139334]  ( EBI )
Publication: Kwan et al., 2016