ZFIN ID: ZDB-EXP-171009-1
Experiment Conditions Description: chemical treatment by injection: CBL0137
chemical treatment by injection: CBL0137
Name: chemical treatment by injection
Definition: Chemical treatment in which the chemical is injected into the zebrafish.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000237]
Name: CBL0137
Synonyms: 1,1'-{9-[2-(isopropylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone, 1,1'-{9-[2-(propan-2-ylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone, 3,6-diacetyl-9-(2-isopropylethyl)-9H-carbazole, CBL-0137 free base, CBLC137, Curaxin 137, Curaxin-137
Definition: A member of the class of carbazoles that is 9H-carbazole which is substituted by acetyl groups at positions 3 and 6, and by a 2-isopropylethyl group on the nitrogen atom (position 9). It is a modulator of histone chaperone FACT (FAcilitates Chromatin Transcription) - interaction of CBL0137 with the FACT complex results in simultaneous NF-kappa beta suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation - and shows antitumour effects in animal models of various cancers.
Ontology: Chebi [CHEBI:138650]
Publication: Zhang et al., 2017