| ZFIN ID: ZDB-EXP-170926-3 |
Experiment Conditions Description: chemical treatment by environment: dabrafenib, chemical treatment by environment: selumetinib
| chemical treatment by environment: dabrafenib |
|---|
| Name: | chemical treatment by environment |
|---|---|
| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | dabrafenib |
|---|---|
| Synonyms: | dabrafenib, N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide |
| Definition: | An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma. |
| Ontology: | ChEBI [CHEBI:75045] ( EBI ) |
| chemical treatment by environment: selumetinib |
|---|
| Name: | chemical treatment by environment |
|---|---|
| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | selumetinib |
|---|---|
| Synonyms: | 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, ARRY 142886, ARRY-142886, ARRY142886, AZD 6244, AZD-6244, AZD6244, selumetinib, selumetinibum |
| Definition: | A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-chlorophenyl)amino, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor. |
| Ontology: | ChEBI [CHEBI:90227] ( EBI ) |
| Publication: | Anelli et al., 2017 |
|---|