| ZFIN ID: ZDB-EXP-170531-7 |
Experiment Conditions Description: chemical treatment by environment: PD 0325901, chemical treatment by environment: miconazole
| chemical treatment by environment: PD 0325901 |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | PD 0325901 |
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| Synonyms: | N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide, PD 325901, PD-0325901, PD-325901, PD0325901 |
| Definition: | A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position 2 by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer). |
| Ontology: | ChEBI [CHEBI:88249] ( EBI ) |
| chemical treatment by environment: miconazole |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | miconazole |
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| Synonyms: | (+-)-miconazole, (RS)-miconazole, 1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole, 1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole, Daktarin IV, Miconazole, Monistat IV (TN), rac-1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, rac-miconazole |
| Definition: | A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes. |
| Ontology: | ChEBI [CHEBI:6923] ( EBI ) |
| Publication: | Yang et al., 2017 |
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