| ZFIN ID: ZDB-EXP-170315-4 |
Experiment Conditions Description: chemical treatment: isotretinoin, chemical treatment: trametinib
| chemical treatment: isotretinoin |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | isotretinoin |
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| Synonyms: | (2Z,4E6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid, (7E,9E,11E,13Z)-retinoic acid, 13-cis-retinoic acid, 13-cis-Vitamin A acid, 13-RA, Accutane, Amnesteem, cis-RA, Claravis, isotretinoin, isotretinoina, isotretinoine, isotretinoino, isotretinoinum, Neovitamin A acid |
| Definition: | A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases. |
| Ontology: | ChEBI [CHEBI:6067] ( EBI ) |
| chemical treatment: trametinib |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | trametinib |
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| Synonyms: | GSK 1120212, JTP 74057, N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide, trametinib, trametinibum |
| Definition: | A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment. |
| Ontology: | ChEBI [CHEBI:75998] ( EBI ) |
| Publication: | He et al., 2016 |
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