ZFIN ID: ZDB-EXP-151231-1
Experiment Conditions Description: physical alteration: anatomical structure, chemical treatment: metronidazole
physical alteration: anatomical structure
Name: physical alteration
Synonyms:
Definition: Experimental condition in which an anatomical structure, cell, or organ has sustained targeted physical change, usually through the use of an instrument.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000229]
Name: anatomical structure
Synonyms: anatomical structures
Definition: Zebrafish anatomical entity that has inherent 3D shape and is generated by coordinated expression of the organism's own genome.
Ontology: Anatomy Ontology [ZFA:0000037]
chemical treatment: metronidazole
Name: chemical treatment
Synonyms:
Definition: Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000111]
Name: metronidazole
Synonyms: 1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole, 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole, 1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-oxyethyl)-2-methyl-5-nitroimidazole, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol, 2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole, 2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole, 2-methyl-5-nitroimidazole-1-ethanol, metronidazol, metronidazole, metronidazolum
Definition: A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Ontology: ChEBI [CHEBI:6909]  ( EBI )
Publication: He et al., 2014