| ZFIN ID: ZDB-EXP-150807-11 |
Experiment Conditions Description: heat shock, chemical treatment: LY-411575
| heat shock |
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| Name: | heat shock |
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| Synonyms: | |
| Definition: | Temperature shock condition in which fish are subjected for a short period of time to temperature higher than the controlled temperature. The standard controlled temperature (according to the zebrafish book) is 28.5 degrees C. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000166] |
| chemical treatment: LY-411575 |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | LY-411575 |
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| Synonyms: | LSN-411575, LY-411575, LY411575, N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-N-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide, N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N(1)-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide |
| Definition: | A dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss. |
| Ontology: | ChEBI [CHEBI:87359] ( EBI ) |
| Publication: | Kantarci et al., 2015 |
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