ZFIN Publication ID PubMed ID Authors Title Journal Year Volume Pages ZDB-PUB-020820-4 12167159 Kobayashi, M., Itoh, K., Suzuki, T., Osanai, H., Nishikawa, K., Katoh, Y., Takagi, Y., and Yamamoto, M. Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system Genes to cells : devoted to molecular & cellular mechanisms 2002 7(8) 807-820 ZDB-PUB-050120-9 15654768 Suzuki, T., Takagi, Y., Osanai, H., Li, L., Takeuchi, M., Katoh, Y., Kobayashi, M., and Yamamoto, M. Pi class glutathione S-transferase genes are regulated by Nrf 2 through an evolutionarily conserved regulatory element in zebrafish The Biochemical journal 2005 388(Pt 1) 65-73 ZDB-PUB-081114-15 19001094 Kobayashi, M., Li, L., Iwamoto, N., Nakajima-Takagi, Y., Kaneko, H., Nakayama, Y., Eguchi, M., Wada, Y., Kumagai, Y., and Yamamoto, M. The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds Molecular and cellular biology 2009 29(2) 493-502 ZDB-PUB-090302-10 19233942 Timme-Laragy, A.R., Van Tiem, L.A., Linney, E.A., and Di Giulio, R.T. Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish Toxicological sciences : an official journal of the Society of Toxicology 2009 109(2) 217-227 ZDB-PUB-100309-15 20200220 Shi, X., and Zhou, B. The Role of Nrf2 and MAPK Pathways in PFOS-induced Oxidative Stress in Zebrafish Embryos Toxicological sciences : an official journal of the Society of Toxicology 2010 115(2) 391-400 ZDB-PUB-101222-1 21143560 Tsujita, T., Li, L., Nakajima, H., Iwamoto, N., Nakajima-Takagi, Y., Ohashi, K., Kawakami, K., Kumagai, Y., Freeman, B.A., Yamamoto, M., and Kobayashi, M. Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish Genes to cells : devoted to molecular & cellular mechanisms 2011 16(1) 46-57 ZDB-PUB-111117-5 22046393 Nakajima, H., Nakajima-Takagi, Y., Tsujita, T., Akiyama, S., Wakasa, T., Mukaigasa, K., Kaneko, H., Tamaru, Y., Yamamoto, M., and Kobayashi, M. Tissue-restricted expression of nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles PLoS One 2011 6(10) e26884 ZDB-PUB-120105-51 22174413 Timme-Laragy, A.R., Karchner, S.I., Franks, D.G., Jenny, M.J., Harbeitner, R.C., Goldstone, J.V., McArthur, A.G., and Hahn, M.E. Nrf2b: novel zebrafish paralog of the oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2) The Journal of biological chemistry 2012 287(7) 4609-4627 ZDB-PUB-121205-45 23174481 Wang, L., and Gallagher, E.P. Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish Toxicology and applied pharmacology 2013 266(2) 177-186 ZDB-PUB-121227-18 23266559 Onyiah, J.C., Sheikh, S.Z., Maharshak, N., Steinbach, E.C., Russo, S.M., Kobayashi, T., Mackey, L.C., Hansen, J.J., Moeser, A.J., Rawls, J.F., Borst, L.B., Otterbein, L.E., and Plevy, S.E. Carbon Monoxide and Heme Oxygenase-1 Prevent Intestinal Inflammation in Mice by Promoting Bacterial Clearance Gastroenterology 2013 144(4) 789-798 ZDB-PUB-131216-1 24298298 Williams, L.M., Timme-Laragy, A.R., Goldstone, J.V., McArthur, A.G., Stegeman, J.J., Smolowitz, R.M., and Hahn, M.E. Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio PLoS One 2013 8(10) e79574 ZDB-PUB-140303-23 24388745 Cox, A.G., Saunders, D.C., Kelsey, P.B., Conway, A.A., Tesmenitsky, Y., Marchini, J.F., Brown, K.K., Stamler, J.S., Colagiovanni, D.B., Rosenthal, G.J., Croce, K.J., North, T.E., and Goessling, W. S-Nitrosothiol Signaling Regulates Liver Development and Improves Outcome following Toxic Liver Injury Cell Reports 2014 6(1) 56-69 ZDB-PUB-140325-4 24652768 Zhang, S., Xu, M., Huang, J., Tang, L., Zhang, Y., Wu, J., Lin, S., and Wang, H. Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish Disease models & mechanisms 2014 7(7) 837-45 ZDB-PUB-160617-3 27306194 Fuse, Y., Nguyen, V.T., Kobayashi, M. Nrf2-dependent protection against acute sodium arsenite toxicity in zebrafish Toxicology and applied pharmacology 2016 305 136-42 ZDB-PUB-160831-1 27576004 Massarsky, A., Bone, A.J., Dong, W., Hinton, D.E., Prasad, G.L., Di Giulio, R.T. AHR2 morpholino knockdown reduces the toxicity of total particulate matter to zebrafish embryos Toxicology and applied pharmacology 2016 309 63-76 ZDB-PUB-160928-7 27671773 Holowiecki, A., O'Shields, B., Jenny, M.J. Characterization of heme oxygenase and biliverdin reductase gene expression in zebrafish (Danio rerio): Basal expression and response to pro-oxidant exposures Toxicology and applied pharmacology 2016 311 74-87 ZDB-PUB-161025-28 27760386 Holowiecki, A., O'Shields, B., Jenny, M.J. Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2017 191 138-151 ZDB-PUB-170607-5 28582729 Sant, K.E., Hansen, J.M., Williams, L.M., Tran, N.L., Goldstone, J.V., Stegeman, J.J., Hahn, M.E., Timme-Laragy, A. The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo Redox Biology 2017 13 207-218 ZDB-PUB-180224-2 29472449 Mukaigasa, K., Tsujita, T., Nguyen, V.T., Li, L., Yagi, H., Fuse, Y., Nakajima-Takagi, Y., Kato, K., Yamamoto, M., Kobayashi, M. Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish Proceedings of the National Academy of Sciences of the United States of America 2018 115(11) 2758-2763 ZDB-PUB-190426-7 31022495 Li, H., Zhang, Q., Li, W., Li, H., Bao, J., Yang, C., Wang, A., Wei, J., Chen, S., Jin, H. Role of Nrf2 in the antioxidation and oxidative stress induced developmental toxicity of honokiol in zebrafish Toxicology and applied pharmacology 2019 373 48-61 ZDB-PUB-191102-1 31665914 Poganik, J.R., Long, M.J.C., Disare, M.T., Liu, X., Chang, S.H., Hla, T., Aye, Y. Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1 FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 33(12) 14636-14652 ZDB-PUB-200221-14 32063256 Sant, K.E., Moreau, H.M., Williams, L.M., Jacobs, H.M., Bowsher, A.M., Boisvert, J.D., Smolowitz, R.M., Pantazis, J., Annunziato, K., Nguyen, M., Timme-Laragy, A. Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling Journal of developmental origins of health and disease 2020 12(1) 132-140 ZDB-PUB-211129-15 34818339 Guan, R., Wen, X.Y., Leung, C.H., Ciano-Oliveira, C.D., Lam, S., Dai, S.Y., Karbassi, F., Mauro, A., Wang, Y., Rotstein, O. Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox PLoS One 2021 16 e0260442 ZDB-PUB-221028-35 36300632 Van Hall-Beauvais, A., Poganik, J.R., Huang, K.T., Parvez, S., Zhao, Y., Lin, H.Y., Liu, X., Long, M.J.C., Aye, Y. Z-REX uncovers a bifurcation in function of Keap1 paralogs eLIFE 2022 11 ZDB-PUB-231002-116 37748761 Chang, S.H., Giong, H.K., Kim, D.Y., Kim, S., Oh, S., Yun, U.J., Lee, J.S., Park, K.W. 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