PUBLICATION

Determination of primary motoneuron identity in developing zebrafish embryos

Authors
Eisen, J.S.
ID
ZDB-PUB-961014-7
Date
1991
Source
Science (New York, N.Y.)   252: 569-572 (Journal)
Registered Authors
Eisen, Judith S.
Keywords
none
MeSH Terms
  • Animals
  • Axonal Transport
  • Axons/physiology
  • Embryo, Nonmammalian/physiology*
  • Interneurons/cytology
  • Interneurons/physiology
  • Motor Neurons/cytology
  • Motor Neurons/physiology
  • Motor Neurons/transplantation*
  • Spinal Cord/embryology*
  • Zebrafish
PubMed
1708527 Full text @ Science
Abstract
The developmental determination of primary motoneurons was investigated by transplanting identified motoneurons in embryonic zebrafish to new spinal cord positions. Some cells moved from the new positions in which they were placed back to their original positions, thus it was difficult to evaluate whether they were determined. Among cells that remained in their new positions, those transplanted about 1 hour before axogenesis developed axonal trajectories that were appropriate for their original soma positions, whereas those transplanted 2 to 3 hours before axogenesis developed morphologies appropriate for their new soma positions. These results suggest that motoneuronal identity is determined before axogenesis.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping