PUBLICATION
Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus
- Authors
- Danos, M.C. and Yost, H.J.
- ID
- ZDB-PUB-961014-198
- Date
- 1996
- Source
- Developmental Biology 177: 96-103 (Journal)
- Registered Authors
- Danos, Maria, Yost, H. Joseph
- Keywords
- none
- MeSH Terms
-
- Animals
- DNA-Binding Proteins/genetics
- Embryo, Nonmammalian/embryology
- Embryonic and Fetal Development/physiology
- Fetal Proteins/genetics
- Heart/embryology*
- Homeodomain Proteins/genetics
- Mutation
- Notochord/embryology*
- T-Box Domain Proteins*
- Transcription Factors/genetics
- Transcription, Genetic
- Xenopus/embryology*
- Zebrafish/embryology*
- Zebrafish Proteins*
- PubMed
- 8660880 Full text @ Dev. Biol.
Citation
Danos, M.C. and Yost, H.J. (1996) Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus. Developmental Biology. 177:96-103.
Abstract
The left-right body axis is coordinately aligned with the orthogonal dorsoventral and anterioposterior body axes. The developmental mechanisms that regulate axis coordination are unknown. Here it is shown that the cardiac left-right orientation in zebrafish (Danio rerio) is randomized in notochord-defective no tail and floating head mutants. no tail (Brachyury) and floating head (Xnot) encode putative transcription factors that are expressed in the organizer and notochord, structures which regulate dorsoventral and anterioposterior development in vertebrate embryos. Results from dorsal tissue extirpation and cardiac primordia explantation indicate that cardiac left-right orientation is dependent on dorsoanterior structures including the notochord and is specified during neural fold stages in Xenopus laevis. Thus, the notochord coordinates the development of all three body axes in the vertebrate body plan.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping