PUBLICATION
Zebrafish neurons express two L1-related molecules during early axonogenesis
- Authors
- Tongiorgi, E., Bernhardt, R.R., and Schachner, M.
- ID
- ZDB-PUB-961014-1132
- Date
- 1995
- Source
- Journal of neuroscience research 42: 547-561 (Journal)
- Registered Authors
- Bernhardt, Robert, Schachner, Melitta
- Keywords
- none
- MeSH Terms
-
- Animals
- Axons/physiology*
- Brain/embryology
- Brain/physiology
- Cell Adhesion Molecules, Neuronal/genetics*
- Cloning, Molecular
- DNA, Complementary/physiology
- Embryo, Nonmammalian/physiology
- Gene Expression Regulation, Developmental/physiology
- In Situ Hybridization
- Leukocyte L1 Antigen Complex
- Membrane Glycoproteins/genetics*
- Mice
- Molecular Sequence Data
- Neurons/physiology*
- Sequence Homology, Amino Acid
- Spinal Cord/embryology
- Spinal Cord/physiology
- Zebrafish/embryology*
- PubMed
- 8568941 Full text @ J. Neurosci. Res.
Citation
Tongiorgi, E., Bernhardt, R.R., and Schachner, M. (1995) Zebrafish neurons express two L1-related molecules during early axonogenesis. Journal of neuroscience research. 42:547-561.
Abstract
Partial clones coding for two L1-related genes, zebrafish L1.1 and L1.2, were isolated from a zebrafish embryonic cDNA library. The homology analysis, based on the deduced amino acid sequences of L1.1 and L1.2, revealed that the two molecules are most closely related to each other and to mouse L1. Analysis by in situ hybridization revealed that during embryonic development of the nervous system the L1.1 and L1.2 messages are restricted to postmitotic neurons and that the onset of expression correlates with the initiation of axonogenesis. L1.1 is expressed by all known classes of neurons, consistent with an important general function during axonal outgrowth. Most of the neurons also express L1.2. However, L1.2 either is undetectable or is expressed at very low levels in the neurons of the olfactory placodes, anterior lateral line/acoustic ganglia complex, posterior lateral line ganglion, and in late developing hindbrain neurons. In the spinal cord, L1.2 message is detected only in a subpopulation of Rohon-Beard cells. This suggests the possibility that different levels of L1.2 expression may serve to distinguish different populations of neurons and their axons.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping