PUBLICATION

Evolutionary insights into heart regeneration

Authors
Xiong, J.W.
ID
ZDB-PUB-201202-16
Date
2020
Source
Cell regeneration (London, England)   9: 23 (Other)
Registered Authors
Xiong, Jing-Wei
Keywords
none
MeSH Terms
none
PubMed
33258016 Full text @ Cell Regen (Lond)
Abstract
Some lower vertebrates such as zebrafish and axolotl have incredible cardiac regenerative potential while mammals have very limited ones. Comparative studies among species have revealed that cardiomyocyte polyploidy, endothermy, and injury-induced activation of certain transcriptional factors including AP1 complexes are critical for cardiomyocyte proliferation and heart regeneration during animal evolution. Gaining insights into these evolutionarily conserved mechanisms will likely lead to achieving heart regeneration in non-regenerative mammals including humans.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping