PUBLICATION

The Dorsal Lateral Habenula-Interpeduncular Nucleus Pathway Is Essential for Left-Right-Dependent Decision Making in Zebrafish

Authors
Cherng, B.W., Islam, T., Torigoe, M., Tsuboi, T., Okamoto, H.
ID
ZDB-PUB-201002-77
Date
2020
Source
Cell Reports   32: 108143 (Journal)
Registered Authors
Okamoto, Hitoshi
Keywords
allocentric, cued information, decision making, directional information, egocentric, habenula, interpeduncular nucleus, learning, left-right distinction, plus-maze
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Brain/physiology
  • Conditioning, Operant/physiology
  • Decision Making/physiology
  • Feeding Behavior/physiology*
  • Functional Laterality/physiology*
  • Habenula/metabolism
  • Habenula/physiology*
  • Interpeduncular Nucleus/physiology
  • Neural Pathways/physiology
  • Zebrafish
PubMed
32937118 Full text @ Cell Rep.
Abstract
How animals behave using suitable information to adapt to the environment is not well known. We address this issue by devising an automated system to let zebrafish exploit either internal (choice of left or right turn) or external (choice of cue color) navigation information to achieve operant behavior by reward reinforcement learning. The results of behavioral task with repeated rule shift indicate that zebrafish can learn operant behavior using both internal-directional and external-cued information. The learning time is reduced as rule shifts are repeated, revealing the capacity of zebrafish to adaptively retrieve the suitable rule memory after training. Zebrafish with an impairment in the neural pathway from the lateral subregion of the dorsal habenula to the interpeduncular nucleus, known to be potentiated in the winners of social conflicts, show specific defects in the application of the internal-directional rule, suggesting the dual roles of this pathway.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping