ZFIN ID: ZDB-PUB-200829-8
Myocardial Infarction Techniques in Adult Mice
Bassat, E., Perez, D.E., Tzahor, E.
Date: 2021
Source: Methods in molecular biology (Clifton, N.J.)   2158: 3-21 (Chapter)
Registered Authors: Perez, Dahlia
Keywords: Cardiac function, Cardiac regeneration, Cardiomyocyte proliferation, Echocardiography, Scar quantification
MeSH Terms:
  • Animals
  • Female
  • Heart/physiopathology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred ICR
  • Myocardial Infarction/physiopathology*
  • Myocytes, Cardiac/cytology*
  • Myocytes, Cardiac/physiology*
  • Regeneration*
PubMed: 32857361 Full text @ Meth. Mol. Biol.
The discovery of endogenous regenerative potential of the heart in zebrafish and neonatal mice has shifted the cardiac regenerative field towards the utilization of intrinsic regenerative mechanisms in the mammalian heart. The goal of these studies is to understand, and eventually apply, the neonatal regenerative mechanisms into adulthood. To facilitate these studies, the last two decades have seen advancements in the development of injury models in adult mice representative of the diversity of cardiac diseases. Here, we provide an overview for a selection of the most common cardiac ischemic injury models and describe a set of methods used to accurately analyze and quantify cardiac outcomes. Importantly, a comprehensive understanding of cardiac regeneration and repair requires a combination of multiple functional, histological, and molecular analyses.