PUBLICATION

Seizing the moment: Zebrafish epilepsy models

Authors
Gawel, K., Langlois, M., Martins, T., van der Ent, W., Tiraboschi, E., Jacmin, M., Crawford, A.D., Esguerra, C.V.
ID
ZDB-PUB-200617-23
Date
2020
Source
Neuroscience and biobehavioral reviews   116: 1-20 (Review)
Registered Authors
Crawford, Alexander, Esguerra, Camila V., Gawel, Kinga Aurelia, van der Ent, Wietske
Keywords
EEG, epilepsy, gene, high-throughput screening, pharmacological models, zebrafish
MeSH Terms
  • Animals
  • Disease Models, Animal
  • Epilepsy*/genetics
  • Seizures
  • Zebrafish*
PubMed
32544542 Full text @ Neurosci. Biobehav. Rev.
Abstract
Zebrafish are now widely accepted as a valuable animal model for a number of different central nervous system (CNS) diseases. They are suitable both for elucidating the origin of these disorders and the sequence of events culminating in their onset, and for use as a high-throughput in vivo drug screening platform. The availability of powerful and effective techniques for genome manipulation allows the rapid modelling of different genetic epilepsies and of conditions with seizures as a core symptom. With this review, we seek to summarize the current knowledge about existing epilepsy/seizures models in zebrafish (both pharmacological and genetic) and compare them with equivalent rodent and human studies. New findings obtained from the zebrafish models are highlighted. We believe that this comprehensive review will highlight the value of zebrafish as a model for investigating different aspects of epilepsy and will help researchers to use these models to their full extent.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping