PUBLICATION

From Tank to Treatment: Modeling Melanoma in Zebrafish

Authors
Frantz, W.T., Ceol, C.J.
ID
ZDB-PUB-200528-4
Date
2020
Source
Cells   9(5): (Review)
Registered Authors
Ceol, Craig
Keywords
Melanoma, genetics, melanocytes, microenvironment, modeling, xenografts, zebrafish
MeSH Terms
  • Animals
  • Disease Models, Animal
  • Genetic Predisposition to Disease
  • Melanocytes/pathology
  • Melanoma/genetics
  • Melanoma/pathology*
  • Neural Crest/pathology
  • Zebrafish/physiology*
PubMed
32455885 Full text @ Cells
Abstract
Melanoma is the deadliest form of skin cancer and one of few cancers with a growing incidence. A thorough understanding of its pathogenesis is fundamental to developing new strategies to combat mortality and morbidity. Zebrafish-due in large part to their tractable genetics, conserved pathways, and optical properties-have emerged as an excellent system to model melanoma. Zebrafish have been used to study melanoma from a single tumor initiating cell, through metastasis, remission, and finally into relapse. In this review, we examine seminal zebrafish studies that have advanced our understanding of melanoma.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping