PUBLICATION

Advancing zebrafish as a model for studying developmental neurotoxicology

Authors
Martin, N.R., Plavicki, J.S.
ID
ZDB-PUB-200403-214
Date
2020
Source
Journal of neuroscience research   98(6): 981-983 (Other)
Registered Authors
Martin, Nathan, Plavicki, Jessica
Keywords
none
MeSH Terms
  • Animals
  • Brain/drug effects*
  • Environmental Exposure*
  • Environmental Pollutants/toxicity*
  • Models, Animal
  • Zebrafish
PubMed
32227499 Full text @ J. Neurosci. Res.
Abstract
The cover photo shows the developing zebrafish nervous system at 5 days post-fertilization. Axon tracts are labeled with an anti-acetylated alpha tubulin antibody. The image, which was acquired on a Zeiss LSM 880 confocal microscope, is a maximum intensity projection of a z-stack that has been color-coded for depth. Major brain regions such as the olfactory bulb, forebrain, habenula, optic tectum, cerebellum, hindbrain, and eye are identifiable. This image is part of a study (Plavicki Lab, Brown University) focused on understanding the impact of toxicant exposures on brain development and activity with the goal of identifyingenvironmental factors that contribute to the etiology of neurodevelopmental disorders.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping