PUBLICATION
The Zebrafish as a Model for Gastrointestinal Tract - Microbe Interactions
- Authors
- Flores, E.M., Nguyen, A.T., Odem, M.A., Eisenhoffer, G.T., Krachler, A.M.
- ID
- ZDB-PUB-191226-29
- Date
- 2019
- Source
- Cellular Microbiology 22(3): e13152 (Review)
- Registered Authors
- Eisenhoffer, George, Nguyen, Anh Trinh
- Keywords
- Danio rerio, Zebrafish, gastrointestinal tract, host-pathogen interactions, infection model, microbiome, microbiota
- MeSH Terms
-
- Animals
- Bacterial Infections
- Disease Models, Animal
- Gastrointestinal Microbiome
- Gastrointestinal Tract/immunology*
- Gastrointestinal Tract/microbiology*
- Gastrointestinal Tract/parasitology*
- Host Microbial Interactions
- Inflammatory Bowel Diseases
- Larva
- Microbial Interactions
- Protozoan Infections
- Zebrafish*
- PubMed
- 31872937 Full text @ Cell. Microbiol.
Citation
Flores, E.M., Nguyen, A.T., Odem, M.A., Eisenhoffer, G.T., Krachler, A.M. (2019) The Zebrafish as a Model for Gastrointestinal Tract - Microbe Interactions. Cellular Microbiology. 22(3):e13152.
Abstract
The zebrafish (Danio rerio) has become a widely used vertebrate model for bacterial, fungal, viral, and protozoan infections. Due to its genetic tractability, large clutch sizes, ease of manipulation, and optical transparency during early life stages, it is a particularly useful model to address questions about the cellular microbiology of host-microbe interactions. Although its use as a model for systemic infections, as well as infections localized to the hindbrain and swimbladder have been thoroughly reviewed, studies focusing on host-microbe interactions in the zebrafish gastrointestinal tract have been neglected. Here, we summarize recent findings regarding the developmental and immune biology of the gastrointestinal tract, drawing parallels to mammalian systems. We discuss the use of adult and larval zebrafish as models for gastrointestinal infections, and more generally, for studies of host-microbe interactions in the gut. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping