PUBLICATION

Precise Drug Delivery by Using PLGA-Based Microspheres and Optical Manipulators

Authors
Liu, H., Li, X., Wei, T., Xu, S., Chen, S., Cheng, S.H., Sun, D.
ID
ZDB-PUB-191214-3
Date
2019
Source
IEEE Transactions on Nanobioscience   19(2): 192-202 (Journal)
Registered Authors
Cheng, Shuk Han
Keywords
none
MeSH Terms
  • Angiogenesis Inducing Agents/pharmacokinetics
  • Angiogenesis Inducing Agents/pharmacology
  • Animals
  • Delayed-Action Preparations
  • Drug Delivery Systems/methods*
  • Embryo, Nonmammalian/metabolism
  • Microscopy, Fluorescence
  • Microspheres*
  • Neovascularization, Physiologic/drug effects
  • Optical Tweezers*
  • Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry
  • Polylactic Acid-Polyglycolic Acid Copolymer*/pharmacokinetics
  • Vascular Endothelial Growth Factor A/pharmacokinetics
  • Vascular Endothelial Growth Factor A/pharmacology
  • Zebrafish
PubMed
31831429 Full text @ IEEE Trans. Nanobioscience
Abstract
The accurate delivery of precise amounts of drugs to a specific location can considerably affect various clinical applications. The precise control of drug amount and position is crucial to a successful drug delivery. This paper proposes the use of poly(lactide-co-glycolicacid) (PLGA)-based microspheres to contain precise amounts of drugs and an optical tweezer manipulator to transport these drug-containing microspheres to their targeted sites in vivo. The drugs were delivered by the PLGA-based microspheres to the yolk sac of zebrafish embryos, and a sustained drug release was observed to examine the anti-angiogenesis and angiogenesis activities. The PLGA-based microspheres degraded in zebrafish, thereby verifying that these microspheres can be used as drug carriers in vivo to ensure good biocompatibility and biodegradation. The proposed precise drug delivery approach can be used in protein tests and drug property characterization in vivo.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping