PUBLICATION

Developing zebrafish experimental animal models relevant to schizophrenia

Authors
Demin, K.A., Meshalkina, D.A., Volgin, A.D., Yakovlev, O.V., de Abreu, M.S., Alekseeva, P.A., Friend, A.J., Lakstygal, A.M., Zabegalov, K., Amstislavskaya, T.G., Strekalova, T., Bao, W., Kalueff, A.V.
ID
ZDB-PUB-190802-9
Date
2019
Source
Neuroscience and biobehavioral reviews   105: 126-133 (Review)
Registered Authors
Kalueff, Allan V.
Keywords
negative symptoms, positive symptoms, rodent models, schizophrenia, translational research, zebrafish
MeSH Terms
  • Animals
  • Behavior, Animal*/physiology
  • Disease Models, Animal*
  • Schizophrenia*/genetics
  • Schizophrenia*/physiopathology
  • Translational Research, Biomedical*
  • Zebrafish*/physiology
PubMed
31369798 Full text @ Neurosci. Biobehav. Rev.
Abstract
Schizophrenia is a severely debilitating, lifelong psychiatric disorder affecting approximately 1% of global population. The pathobiology of schizophrenia remains poorly understood, necessitating further translational research in this field. Experimental (animal) models are becoming indispensable for studying schizophrenia-related phenotypes and drugs. Mounting evidence suggests the zebrafish (Danio rerio) as a useful tool to model various phenotypes relevant to schizophrenia. In addition to their complex robust behaviors, zebrafish possess high genetic and physiological homology to humans, and are also sensitive to drugs known to reduce or promote schizophrenia clinically. Here, we summarize findings on zebrafish application to modeling schizophrenia, as well as discuss recent progress and remaining challenges in this field. We also emphasize the need in further development and wider use of zebrafish models for schizophrenia to better understand its pathogenesis and enhance the search for new effective antipsychotics.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping