PUBLICATION

Cinnamon attenuates adiposity and affects the expression of metabolic genes in Diet-Induced obesity model of zebrafish

Authors
Kaur, N., Chugh, H., Tomar, V., Sakharkar, M.K., Dass, S.K., Chandra, R.
ID
ZDB-PUB-190719-21
Date
2019
Source
Artificial cells, nanomedicine, and biotechnology   47: 2930-2939 (Journal)
Registered Authors
Keywords
Cinnamon, Obesity, diet-induced obesity model, metabolic disorders, zebrafish
MeSH Terms
  • Adiposity/drug effects*
  • Animals
  • Blood Glucose/metabolism*
  • Body Mass Index
  • Body Size/drug effects
  • Body Weight/drug effects
  • Cinnamomum zeylanicum/chemistry*
  • Diet/adverse effects*
  • Disease Models, Animal
  • Gene Expression Regulation/drug effects*
  • Liver/drug effects
  • Liver/pathology
  • Obesity/etiology
  • Obesity/genetics
  • Obesity/metabolism*
  • Obesity/pathology*
  • Triglycerides/blood
  • Zebrafish
PubMed
31317780 Full text @ Artif Cells Nanomed Biotechnol
Abstract
The prevalence of obesity is increasing at an alarming rate worldwide with about 30% of the world population classified as obese. Obese body structure results when energy intake exceeds energy expenditure in an individual. Increase in the consumption of high-energy eatables, in the context of portion and energy provided, has resulted in obese populations which is becoming the leading cause of metabolic disorders related to morbidity. The obesity-related comorbidity is an enormous liability on health services and will affect measures taken in tackling the increasing obesity rate. Prevention of an obese phenotype is the most suitable long-term strategy. Another approach towards the treatment of obesity is weight management through phytotherapeutics. In this study, we explored the anti-obesity effects of Cinnamon (Cinnamomum zeylanicum) in adult male zebrafish. Through BMI measurements, blood glucose level analyses, serum triglyceride analyses, Oil Red O staining as well as quantitative Real Time-PCR, the ability of cinnamon to reduce metabolic disorders associated with obesity is investigated for the first time in a zebrafish model. Our studies indicate that cinnamon ameliorates the genotypic and phonotypic characteristics associated with obesity through lowering of BMI, blood glucose, triglyceride levels, lipid levels in the liver and through gene modulation.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping