PUBLICATION

Neuropharmacology, pharmacogenetics and pharmacogenomics of aggression: the zebrafish model

Authors
de Abreu, M.S., Giacomini, A.C.V.V., Genario, R., Dos Santos, B.E., da Rosa, L.G., Demin, K.A., Wappler-Guzzetta, E., Kalueff, A.V.
ID
ZDB-PUB-190203-5
Date
2019
Source
Pharmacological research   141: 602-608 (Review)
Registered Authors
Kalueff, Allan V.
Keywords
CNS, aggression, animal models, epigenetics, pharmacological modulation
MeSH Terms
  • Aggression*/drug effects
  • Animals
  • Central Nervous System Agents/pharmacology
  • Central Nervous System Diseases/drug therapy
  • Central Nervous System Diseases/genetics*
  • Central Nervous System Diseases/pathology
  • Disease Models, Animal*
  • Neuropharmacology
  • Pharmacogenetics
  • Translational Research, Biomedical
  • Zebrafish/genetics*
  • Zebrafish/physiology
PubMed
30708051 Full text @ Pharmacol. Res.
Abstract
The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in neurobehavioral research. Aggression is a common symptom of many CNS disorders, has some genetic deterinants and can be modulated pharmacologically in humans and animal model species. Mounting evidence suggests zebrafish as a useful tool to study neurobiology of aggression, and its pharmacological and genetic regulation. Here, we discuss mechanisms of zebrafish aggression and their pharmacological, pharmacogenetic and pharmacogenomic models, as well as recent developments and existing challenges in this field. We also emphasize the growing utility of zebrafish models in translational neuropharmacological research of aggression, fostering future discoveries of potential therapeutic agents for aggressive behavior.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping