PUBLICATION

Water Waves to Sound Waves: Using Zebrafish to Explore Hair Cell Biology

Authors
Pickett, S.B., Raible, D.W.
ID
ZDB-PUB-190113-22
Date
2019
Source
Journal of the Association for Research in Otolaryngology : JARO   20(1): 1-19 (Review)
Registered Authors
Raible, David
Keywords
auditory system, hearing loss, lateral line system, mechanosensation
MeSH Terms
  • Animals
  • Cell Death
  • Cell Polarity
  • Eye Proteins/physiology
  • Glutaredoxins/genetics
  • Hair Cells, Auditory/physiology*
  • Hearing Loss/genetics
  • Mechanotransduction, Cellular/physiology
  • Models, Animal
  • Myosin VIIa/genetics
  • Sound
  • Water
  • Zebrafish/physiology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/physiology
PubMed
30635804 Full text @ J. Assoc. Res. Otolaryngol.
Abstract
Although perhaps best known for their use in developmental studies, over the last couple of decades, zebrafish have become increasingly popular model organisms for investigating auditory system function and disease. Like mammals, zebrafish possess inner ear mechanosensory hair cells required for hearing, as well as superficial hair cells of the lateral line sensory system, which mediate detection of directional water flow. Complementing mammalian studies, zebrafish have been used to gain significant insights into many facets of hair cell biology, including mechanotransduction and synaptic physiology as well as mechanisms of both hereditary and acquired hair cell dysfunction. Here, we provide an overview of this literature, highlighting some of the particular advantages of using zebrafish to investigate hearing and hearing loss.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping