PUBLICATION

Hematopoietic Cytokine Gene Duplication in Zebrafish Erythroid and Myeloid Lineages

Authors
Oltova, J., Svoboda, O., Bartunek, P.
ID
ZDB-PUB-190109-11
Date
2018
Source
Frontiers in cell and developmental biology   6: 174 (Review)
Registered Authors
Bartunek, Petr, Oltova, Jana, Svoboda, Ondrej
Keywords
cytokine, erythropoiesis, genome duplication, hematopoiesis, myelopoiesis, zebrafish
MeSH Terms
none
PubMed
30619854 Full text @ Front Cell Dev Biol
Abstract
Hematopoiesis is a precisely orchestrated process regulated by the activity of hematopoietic cytokines and their respective receptors. Due to an extra round of whole genome duplication during vertebrate evolution in teleost fish, zebrafish have two paralogs of many important genes, including genes involved in hematopoiesis. Importantly, these duplication events brought increased level of complexity in such cases, where both ligands and receptors have been duplicated in parallel. Therefore, precise understanding of binding specificities between duplicated ligand-receptor signalosomes as well as understanding of their differential expression provide an important basis for future studies to better understand the role of duplication of these genes. However, although many recent studies in the field have partly addressed functional redundancy or sub-specialization of some of those duplicated paralogs, this information remains to be scattered over many publications and unpublished data. Therefore, the focus of this review is to provide an overview of recent findings in the zebrafish hematopoietic field regarding activity, role and specificity of some of the hematopoietic cytokines with emphasis on crucial regulators of the erythro-myeloid lineages.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping