PUBLICATION
Carbon dots: promising biomaterials for bone-specific imaging and drug delivery
- Authors
- Peng, Z., Miyanji, E.H., Zhou, Y., Pardo, J., Hettiarachchi, S.D., Li, S., Blackwelder, P.L., Skromne, I., Leblanc, R.M.
- ID
- ZDB-PUB-181220-15
- Date
- 2017
- Source
- Nanoscale 9: 17533-17543 (Journal)
- Registered Authors
- Skromne, Isaac
- Keywords
- none
- MeSH Terms
-
- Animals
- Biocompatible Materials/chemistry*
- Bone and Bones/diagnostic imaging*
- Carbon/chemistry*
- Drug Carriers/chemistry*
- Embryo, Nonmammalian
- Quantum Dots*
- Zebrafish
- PubMed
- 29110000 Full text @ Nanoscale
Citation
Peng, Z., Miyanji, E.H., Zhou, Y., Pardo, J., Hettiarachchi, S.D., Li, S., Blackwelder, P.L., Skromne, I., Leblanc, R.M. (2017) Carbon dots: promising biomaterials for bone-specific imaging and drug delivery. Nanoscale. 9:17533-17543.
Abstract
Bone-related diseases and dysfunctions are heavy burdens on our increasingly aged society. One important strategy to relieve this problem is through early detection and treatment of bone-related diseases. Towards this goal, there has been constant interest in developing novel bone-specific materials for imaging and drug delivery. Currently, however, materials that have high affinity and specificity towards bone are very limited. Carbon dots (C-dots) synthesized from carbon nanopowder bind to calcified bones in vivo with high affinity and specificity. In this study we show that bone binding is highly unique to a specific type of C-dot, and that this binding is non-toxic. Significantly, C-dots derived from other raw materials did not show any bone binding properties. These differences are attributed to the differences in surface chemistry of C-dot preparations, highlighting the heterogeneous nature of C-dots. Importantly, bone-binding by carbon nanopowder derived C-dots is not significantly altered by chemical functionalization of their surface. These unique properties indicate the potential applications of carbon nanopowder-derived C-dots as highly bone-specific bioimaging agents and drug carriers.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping