PUBLICATION

Epigenetic Regulation of Organ Regeneration in Zebrafish

Authors
Zhu, X., Xiao, C., Xiong, J.W.
ID
ZDB-PUB-181219-2
Date
2018
Source
Journal of cardiovascular development and disease   5(4): (Review)
Registered Authors
Xiong, Jing-Wei
Keywords
DNA methylation, SWI/SNF complex, histone modification, miRNA, regeneration, zebrafish
MeSH Terms
none
PubMed
30558240 Full text @ J Cardiovasc Dev Dis
Abstract
The zebrafish is broadly used for investigating de novo organ regeneration, because of its strong regenerative potential. Over the past two decades of intense study, significant advances have been made in identifying both the regenerative cell sources and molecular signaling pathways in a variety of organs in adult zebrafish. Epigenetic regulation has gradually moved into the center-stage of this research area, aided by comprehensive work demonstrating that DNA methylation, histone modifications, chromatin remodeling complexes, and microRNAs are essential for organ regeneration. Here, we present a brief review of how these epigenetic components are induced upon injury, and how they are involved in sophisticated organ regeneration. In addition, we highlight several prospective research directions and their potential implications for regenerative medicine.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping