PUBLICATION
Tissue Regeneration Enhancer Elements: A Way to Unlock Endogenous Healing Power
- Authors
- Yang, K., Kang, J.
- ID
- ZDB-PUB-181130-26
- Date
- 2018
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 248(1): 34-42 (Review)
- Registered Authors
- Kang, Junsu
- Keywords
- Regeneration, Zebrafish, appendage, cancer, enhancer, epigenetics, heart, injury, mouse, salamander, transcription
- MeSH Terms
-
- Animals
- Biological Evolution
- Enhancer Elements, Genetic*
- Humans
- Regeneration/genetics*
- Regenerative Medicine/methods*
- Regulatory Elements, Transcriptional
- Wound Healing/genetics
- PubMed
- 30291668 Full text @ Dev. Dyn.
Citation
Yang, K., Kang, J. (2018) Tissue Regeneration Enhancer Elements: A Way to Unlock Endogenous Healing Power. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(1):34-42.
Abstract
Regenerative capacity is widespread throughout almost all animal phyla. However, the distribution pattern remains incompletely understood. Various examples show that very closely related species display different regenerative capacities. Why and how have diverse regenerative capacities evolved across species? One prevailing thought in the field of regeneration is that most regeneration-associated factors are evolutionarily conserved, suggesting the existence of an innate tissue regeneration ability in all species. However, its regulation is differentially controlled in distinct species, resulting in heterogeneous regenerative capabilities. In this review, we discuss regeneration-associated enhancers, the key cis-regulatory elements controlling gene expression, their underlying molecular mechanisms, and their influence on regenerative capacity. Understanding the regulatory mechanisms of regeneration enhancers can provide fundamental insights into tissue regeneration and further help us develop therapeutic strategies to unlock latent healing powers in humans. Developmental Dynamics 2018. © 2018 Wiley Periodicals, Inc.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping