PUBLICATION

Legal aspects of zebrafish neuropharmacology and neurotoxicology research

Authors
de Abreu, M.S., Giacomini, A.C.V.V., Echevarria, D.J., Kalueff, A.V.
ID
ZDB-PUB-181127-11
Date
2018
Source
Regulatory toxicology and pharmacology : RTP   101: 65-70 (Other)
Registered Authors
Kalueff, Allan V.
Keywords
3Rs, Animal welfare regulations, Pharmacology, Toxicology
MeSH Terms
  • Animal Experimentation/ethics
  • Animal Experimentation/legislation & jurisprudence
  • Animals
  • Central Nervous System Agents/toxicity
  • Controlled Substances
  • Disease Models, Animal*
  • Drug Discovery
  • Neuropharmacology/ethics
  • Neuropharmacology/legislation & jurisprudence
  • Pain
  • Stress, Physiological
  • Zebrafish*
PubMed
30453007 Full text @ Regul. Toxicol. Pharmacol.
Abstract
Despite the growing emphasis on translational neuropharmacology and drug discovery research, the legality underlying these fields are seldom considered. The zebrafish (Danio rerio) is an increasingly utilized model organism in neuropharmacology and neurotoxicology. As the acceptance of zebrafish in biomedicine continues to grow, the legal aspects of their applications remain outpaced by this exponential growth. Therefore, there is a need to evaluate the legal aspects of zebrafish applications to CNS drug research. Here, we discuss a wide range of regulatory topics relevant to zebrafish research, such as the bioethics of experimentation (including studies of stress and pain), welfare protection laws, the recent advances in CNS drug discovery, and specific legal aspects of controlled substance research in this aquatic species. The conceptualization and understanding of the zebrafish welfare and its promise as a model in toxicology can also potentially shape environmental protection practices and inform policy making.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping