PUBLICATION
Genetic Renal Diseases: The Emerging Role of Zebrafish Models
- Authors
- Elmonem, M.A., Berlingerio, S.P., van den Heuvel, L.P., de Witte, P.A., Lowe, M., Levtchenko, E.N.
- ID
- ZDB-PUB-180913-6
- Date
- 2018
- Source
- Cells 7(9): (Review)
- Registered Authors
- Lowe, Martin
- Keywords
- CRISPR, genetic renal diseases, morpholino, new therapies, pathophysiology, pronephros, zebrafish
- MeSH Terms
- none
- PubMed
- 30200518 Full text @ Cells
Citation
Elmonem, M.A., Berlingerio, S.P., van den Heuvel, L.P., de Witte, P.A., Lowe, M., Levtchenko, E.N. (2018) Genetic Renal Diseases: The Emerging Role of Zebrafish Models. Cells. 7(9).
Abstract
The structural and functional similarity of the larval zebrafish pronephros to the human nephron, together with the recent development of easier and more precise techniques to manipulate the zebrafish genome have motivated many researchers to model human renal diseases in the zebrafish. Over the last few years, great advances have been made, not only in the modeling techniques of genetic diseases in the zebrafish, but also in how to validate and exploit these models, crossing the bridge towards more informative explanations of disease pathophysiology and better designed therapeutic interventions in a cost-effective in vivo system. Here, we review the significant progress in these areas giving special attention to the renal phenotype evaluation techniques. We further discuss the future applications of such models, particularly their role in revealing new genetic diseases of the kidney and their potential use in personalized medicine.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping