PUBLICATION

Development of vestibular behaviors in zebrafish

Authors
Bagnall, M.W., Schoppik, D.
ID
ZDB-PUB-180630-13
Date
2018
Source
Current opinion in neurobiology   53: 83-89 (Other)
Registered Authors
Schoppik, David
Keywords
none
MeSH Terms
  • Animals
  • Behavior, Animal/physiology*
  • Larva/growth & development*
  • Neural Pathways/growth & development*
  • Postural Balance/physiology*
  • Vestibule, Labyrinth/growth & development*
  • Zebrafish/growth & development*
PubMed
29957408 Full text @ Curr. Opin. Neurobiol.
Abstract
Most animals orient their bodies with respect to gravity to facilitate locomotion and perception. The neural circuits responsible for these orienting movements have long served as a model to address fundamental questions in systems neuroscience. Though postural control is vital, we know little about development of either balance reflexes or the neural circuitry that produces them. Recent work in a genetically and optically accessible vertebrate, the larval zebrafish, has begun to reveal the mechanisms by which such vestibular behaviors and circuits come to function. Here we highlight recent work that leverages the particular advantages of the larval zebrafish to illuminate mechanisms of postural development, the role of sensation for balance circuit development, and the organization of developing vestibular circuits. Further, we frame open questions regarding the developmental mechanisms for functional circuit assembly and maturation where studying the zebrafish vestibular system is likely to open new frontiers.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping