PUBLICATION
Connexin Communication Compartments and Wound Repair in Epithelial Tissue
- Authors
- Chanson, M., Watanabe, M., O'Shaughnessy, E.M., Zoso, A., Martin, P.E.
- ID
- ZDB-PUB-180513-4
- Date
- 2018
- Source
- International Journal of Molecular Sciences 19(5): (Review)
- Registered Authors
- Watanabe, Masakatsu
- Keywords
- connexin, epithelial tissue, inflammation, pannexin, wound healing, zebrafish models
- MeSH Terms
-
- Animals
- Connexins/metabolism*
- Epithelium/metabolism
- Epithelium/pathology
- Gap Junctions/metabolism
- Gap Junctions/pathology
- Wound Healing/physiology
- Zebrafish
- PubMed
- 29751558 Full text @ Int. J. Mol. Sci.
Citation
Chanson, M., Watanabe, M., O'Shaughnessy, E.M., Zoso, A., Martin, P.E. (2018) Connexin Communication Compartments and Wound Repair in Epithelial Tissue. International Journal of Molecular Sciences. 19(5).
Abstract
Epithelial tissues line the lumen of tracts and ducts connecting to the external environment. They are critical in forming an interface between the internal and external environment and, following assault from environmental factors and pathogens, they must rapidly repair to maintain cellular homeostasis. These tissue networks, that range from a single cell layer, such as in airway epithelium, to highly stratified and differentiated epithelial surfaces, such as the epidermis, are held together by a junctional nexus of proteins including adherens, tight and gap junctions, often forming unique and localised communication compartments activated for localised tissue repair. This review focuses on the dynamic changes that occur in connexins, the constituent proteins of the intercellular gap junction channel, during wound-healing processes and in localised inflammation, with an emphasis on the lung and skin. Current developments in targeting connexins as corrective therapies to improve wound closure and resolve localised inflammation are also discussed. Finally, we consider the emergence of the zebrafish as a concerted whole-animal model to study, visualise and track the events of wound repair and regeneration in real-time living model systems.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping