PUBLICATION

Atrazine affects craniofacial chondrogenesis and axial skeleton mineralization in zebrafish ( Danio rerio)

Authors
Walker, B.S., Kramer, A.G., Lassiter, C.S.
ID
ZDB-PUB-180327-8
Date
2018
Source
Toxicology and industrial health   34(5): 329-338 (Journal)
Registered Authors
Lassiter, Christopher S.
Keywords
Zebrafish, atrazine, cartilage, craniofacial, endocrine
MeSH Terms
  • Animals
  • Atrazine/toxicity*
  • Chondrogenesis/drug effects*
  • Craniofacial Abnormalities/chemically induced
  • Craniofacial Abnormalities/diagnosis*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Embryo, Nonmammalian/drug effects
  • Endocrine Disruptors/toxicity
  • Heart Rate/drug effects
  • Herbicides/toxicity*
  • Larva/drug effects
  • Water Pollutants, Chemical/toxicity
  • Zebrafish/embryology*
  • Zebrafish/growth & development*
PubMed
29575980 Full text @ Toxicol. Ind. Health
Abstract
Atrazine is a commonly used herbicide that has previously been implicated as an endocrine-disrupting compound. Previous studies have shown that estrogenic endocrine-disrupting compounds affect the development of the heart, cartilage, and bone in zebrafish ( Danio rerio). To determine whether atrazine has effects similar to other endocrine disruptors, zebrafish embryos were treated with a range of atrazine concentrations. Atrazine treatment at a low concentration of 0.1 µM resulted in significant differences in craniofacial cartilage elements, while concentrations ≥1 µM led to decreased survival and increased heart rates. Fish treated with ≥1 µM atrazine also developed with delayed vertebrae mineralization. Higher concentrations of atrazine caused gross craniofacial defects and decreased hatching rates. Further studies into the molecular pathways disrupted in these developmental processes could shed light on a link between endocrine-disrupting compounds and developmental abnormalities.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping