PUBLICATION
Regeneration of Organs and Appendages in Zebrafish: A Window into Underlying Control Mechanisms
- Authors
- Antos, C., Knopf, F., Brand, M.
- ID
- ZDB-PUB-171205-17
- Date
- 2016
- Source
- Citable reviews in the life sciences : 1-17 (Review)
- Registered Authors
- Antos, Christopher, Brand, Michael, Knopf, Franziska
- Keywords
- zebrafish, regeneration, fin, brain, spinal cord, heart, stem cells, progenitor cells
- MeSH Terms
- none
- PubMed
- none Full text @ els
Citation
Antos, C., Knopf, F., Brand, M. (2016) Regeneration of Organs and Appendages in Zebrafish: A Window into Underlying Control Mechanisms. Citable reviews in the life sciences. :1-17.
Abstract
The ability to regenerate organs and appendages is not universal among animals. Humans have a rather limited capacity to regenerate after an injury, while other vertebrates such as the zebrafish are capable of regenerating many anatomical structures. It is unknown why different vertebrates have such differences in regenerative capacity, so studying animal models that do regenerate will allow us to know what is needed to regenerate. Zebrafish research is not only able to tell us what mechanisms are involved in regeneration, but it also shows us that there are different regeneration strategies: some use stem cells while other create progenitors from differentiated tissue cells. This article details how zebrafish uses and regulates either differentiated tissue cells or stem cells to regenerate. We focus on four structures – fin appendage, brain, spinal cord and heart – and describe how current cell and molecular discoveries from these regenerating fish structures contribute to our understanding of general principles of regenerative biology.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping