PUBLICATION
Preclinical testing of the glycogen synthase kinase-3β inhibitor tideglusib for rhabdomyosarcoma
- Authors
- Bharathy, N., Svalina, M.N., Settelmeyer, T.P., Cleary, M.M., Berlow, N.E., Airhart, S.D., Xiang, S., Keck, J., Hayden, J.B., Shern, J.F., Mansoor, A., Lathara, M., Srinivasa, G., Langenau, D.M., Keller, C.
- ID
- ZDB-PUB-171004-10
- Date
- 2017
- Source
- Oncotarget 8: 62976-62983 (Journal)
- Registered Authors
- Langenau, David
- Keywords
- GSK3β, myodifferentiation, patient-derived xenograft, preclinical testing, rhabdomyosarcoma
- MeSH Terms
- none
- PubMed
- 28968964 Full text @ Oncotarget
Citation
Bharathy, N., Svalina, M.N., Settelmeyer, T.P., Cleary, M.M., Berlow, N.E., Airhart, S.D., Xiang, S., Keck, J., Hayden, J.B., Shern, J.F., Mansoor, A., Lathara, M., Srinivasa, G., Langenau, D.M., Keller, C. (2017) Preclinical testing of the glycogen synthase kinase-3β inhibitor tideglusib for rhabdomyosarcoma. Oncotarget. 8:62976-62983.
Abstract
Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma. RMS often arise from myogenic precursors and displays a poorly differentiated skeletal muscle phenotype most closely resembling regenerating muscle. GSK3β is a ubiquitously expressed serine-threonine kinase capable of repressing the terminal myogenic differentiation program in cardiac and skeletal muscle. Recent unbiased chemical screening efforts have prioritized GSK3β inhibitors as inducers of myodifferentiation in RMS, suggesting efficacy as single agents in suppressing growth and promoting self-renewal in zebrafish transgenic embryonal RMS (eRMS) models in vivo. In this study, we tested the irreversible GSK3β-inhibitor, tideglusib for in vivo efficacy in patient-derived xenograft models of both alveolar rhabdomyosarcoma (aRMS) and eRMS. Tideglusib had effective on-target pharmacodynamic efficacy, but as a single agent had no effect on tumor progression or myodifferentiation. These results suggest that as monotherapy, GSK3β inhibitors may not be a viable treatment for aRMS or eRMS.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping