PUBLICATION

Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms

Authors
Heckler, K., Kroll, J.
ID
ZDB-PUB-170920-5
Date
2017
Source
International Journal of Molecular Sciences   18(9): (Review)
Registered Authors
Kroll, Jens
Keywords
diabetes mellitus, glyoxalase, hyperglycemia, reactive metabolites, zebrafish
MeSH Terms
  • Animals
  • Diabetic Angiopathies/genetics*
  • Diabetic Angiopathies/pathology
  • Disease Models, Animal*
  • Microvessels/metabolism
  • Microvessels/pathology
  • Zebrafish/genetics*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed
28925940 Full text @ Int. J. Mol. Sci.
Abstract
Diabetes mellitus (DM) is a crucial metabolic disease that leads to severe disorders. These include macrovascular complications such as myocardial infarction, stroke, and peripheral artery disease and microvascular complications including diabetic nephropathy, neuropathy, and retinopathy. Diabetes mellitus, along with its associated organ pathologies, is one of the key problems in today's medicine. Zebrafish is an upcoming disease model organism in diabetes research. Its glucose metabolism and the pathways of reactive metabolite formation are very similar to those of humans. Moreover, several physiological and pathophysiological pathways that also exist in humans and other mammals have been identified in this species or are currently under intense investigation. Zebrafish offer sophisticated imaging techniques and allow simple and fast genetic and pharmacological approaches with a high throughput. In this review, we highlight achievements and mechanisms concerning microvascular complications discovered in zebrafish, and we discuss the advantages and disadvantages of zebrafish as a model for studying diabetic complications.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping