PUBLICATION
Behavioural responses of zebrafish larvae to acute ethosuximide exposure
- Authors
- Ji, Y., Lin, J., Peng, X., Liu, X., Li, F., Zhang, Y., Guo, N., Li, Q.
- ID
- ZDB-PUB-170526-15
- Date
- 2017
- Source
- Behavioural pharmacology 28(6): 428-440 (Journal)
- Registered Authors
- Li, Qiang
- Keywords
- none
- MeSH Terms
-
- Animals
- Anti-Anxiety Agents/pharmacology
- Anticonvulsants/pharmacology
- Anxiety
- Behavior, Animal/drug effects
- Darkness
- Ethosuximide/pharmacology*
- Larva/metabolism
- Light
- Locomotion/drug effects
- Motor Activity/drug effects
- Photic Stimulation
- Zebrafish/embryology
- Zebrafish/metabolism
- Zebrafish/physiology*
- PubMed
- 28537944 Full text @ Behav. Pharmacol.
Citation
Ji, Y., Lin, J., Peng, X., Liu, X., Li, F., Zhang, Y., Guo, N., Li, Q. (2017) Behavioural responses of zebrafish larvae to acute ethosuximide exposure. Behavioural pharmacology. 28(6):428-440.
Abstract
The anticonvulsant drug ethosuximide has shown diverse anxiety-related activity in rodents, but research in zebrafish is limited. To evaluate the effects of acute ethosuximide exposure on locomotor activity and anxiety-related thigmotaxis behaviours of zebrafish larvae, the activity of AB strain zebrafish larvae at 5 and 7 days postfertilization (dpf) was analysed under normal constant illumination and stressful light-dark transitions. Under constant illumination, ethosuximide at concentrations of 2, 5 and 10 mmol/l increased the distances travelled and intensified locomotor responses to a novel environment. In addition, 40 mmol/l ethosuximide decreased the travel distance and attenuated the locomotor response to darkness. The effects were age related. Under constant illumination, ethosuximide at 40 mmol/l reduced thigmotaxis behaviours in larvae at both ages. Under the light-dark transition, 5 mmol/l ethosuximide reduced thigmotaxis behaviours in 7-dpf larvae. We concluded that under constant lighting, ethosuximide at low concentrations (2, 5 and 10 mmol/l) stimulated the locomotor activity of zebrafish larvae, whereas a high concentration (40 mmol/l) inhibited the activity. Ethosuximide at a low concentration (5 mmol/l) showed anxiolytic effects during the stressful light-dark transition in 7-dpf larvae. The effects of ethosuximide were age and concentration related.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping