PUBLICATION

From neuron to behavior: Sensory-motor coordination of zebrafish turning behavior

Authors
Umeda, K., Shoji, W.
ID
ZDB-PUB-170323-12
Date
2017
Source
Development, growth & differentiation   59(3): 107-114 (Review)
Registered Authors
Shoji, Wataru
Keywords
Channelrhodopsin, Rohon-Beard neuron, escape behavior, optogenetics, zebrafish
MeSH Terms
  • Animals
  • Larva/cytology
  • Larva/physiology
  • Mechanotransduction, Cellular/physiology
  • Neurons/cytology
  • Neurons/physiology
  • Optogenetics/methods
  • Zebrafish/physiology*
PubMed
28326550 Full text @ Dev. Growth Diff.
Abstract
Recent development of optogenetics brought non-invasive neural activation in living organisms. Transparent zebrafish larva is one of the suitable animal models for this technique, which enables us to investigate neural circuits for behaviors based on a whole individual nervous system. In this article we review our recent finding that suggests sensory-motor coordination in larval zebrafish escape behavior. When water vibration stimulates mechanosensory Rohon-Beard (RB) neurons, intra-spinal reflex circuit launches contralateral trunk muscle contraction that makes rapid body curvature for turning. In addition, positional information of the stimulus is conveyed to supra-spinal circuits, and then regulates the curvature strength for appropriate escape pathway from the threat. Sensory-motor coordination is a fundamental feature to adapt behaviors to environment, and zebrafish larvae would be an excellent model for elucidating its neural backbones.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping