PUBLICATION

The Hypocretin/Orexin Neuronal Networks in Zebrafish

Authors
Elbaz, I., Levitas-Djerbi, T., Appelbaum, L.
ID
ZDB-PUB-161225-1
Date
2017
Source
Current topics in behavioral neurosciences   33: 75-92 (Chapter)
Registered Authors
Appelbaum, Lior, Elbaz, Idan, Levitas-Djerbi, Tali
Keywords
Behavior, Hypocretin, Narcolepsy, Orexin, Sleep, Zebrafish
MeSH Terms
  • Animals
  • Behavior, Animal/physiology*
  • Brain/metabolism
  • Neurons/metabolism*
  • Orexins/metabolism*
  • Signal Transduction/physiology*
  • Zebrafish
PubMed
28012092 Full text @ Curr. Top. Behav. Neurosci.
Abstract
The hypothalamic Hypocretin/Orexin (Hcrt) neurons secrete two Hcrt neuropeptides. These neurons and peptides play a major role in the regulation of feeding, sleep wake cycle, reward-seeking, addiction, and stress. Loss of Hcrt neurons causes the sleep disorder narcolepsy. The zebrafish has become an attractive model to study the Hcrt neuronal network because it is a transparent vertebrate that enables simple genetic manipulation, imaging of the structure and function of neuronal circuits in live animals, and high-throughput monitoring of behavioral performance during both day and night. The zebrafish Hcrt network comprises ~16-60 neurons, which similar to mammals, are located in the hypothalamus and widely innervate the brain and spinal cord, and regulate various fundamental behaviors such as feeding, sleep, and wakefulness. Here we review how the zebrafish contributes to the study of the Hcrt neuronal system molecularly, anatomically, physiologically, and pathologically.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping