PUBLICATION

Zebrafish adult pigment stem cells are multipotent and form pigment cells by a progressive fate restriction process: Clonal analysis identifies shared origin of all pigment cell types

Authors
Kelsh, R.N., Sosa, K.C., Owen, J.P., Yates, C.A.
ID
ZDB-PUB-161224-3
Date
2017
Source
BioEssays : news and reviews in molecular, cellular and developmental biology   39(3): (Review)
Registered Authors
Kelsh, Robert
Keywords
iridophore, melanocyte, neural crest, pigment pattern formation, stem cell, zebrafish
MeSH Terms
  • Animals
  • Metamorphosis, Biological
  • Neural Crest*
  • Pigmentation
  • Stem Cells
  • Zebrafish/embryology*
PubMed
28009049 Full text @ Bioessays
Abstract
Skin pigment pattern formation is a paradigmatic example of pattern formation. In zebrafish, the adult body stripes are generated by coordinated rearrangement of three distinct pigment cell-types, black melanocytes, shiny iridophores and yellow xanthophores. A stem cell origin of melanocytes and iridophores has been proposed although the potency of those stem cells has remained unclear. Xanthophores, however, seemed to originate predominantly from proliferation of embryonic xanthophores. Now, data from Singh et al. shows that all three cell-types derive from shared stem cells, and that these cells generate peripheral neural cell-types too. Furthermore, clonal compositions are best explained by a progressive fate restriction model generating the individual cell-types. The numbers of adult pigment stem cells associated with the dorsal root ganglia remain low, but progenitor numbers increase significantly during larval development up to metamorphosis, likely via production of partially restricted progenitors on the spinal nerves.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes