PUBLICATION

Genomic and Transcriptomic Approaches to Study Cancer in Small Aquarium Fish Models

Authors
Regneri, J., Klotz, B., Schartl, M.
ID
ZDB-PUB-160810-14
Date
2016
Source
Advances in genetics   95: 31-63 (Chapter)
Registered Authors
Schartl, Manfred
Keywords
Array CGH, Cancer models, Deep-sequencing, Exome-sequencing, Genome-wide, Medaka, Microarray, RNA-seq, Xiphophorus, Zebrafish
MeSH Terms
  • Animals
  • Gene Expression Profiling/methods
  • Genomics/methods
  • Humans
  • Models, Animal
  • Neoplasms/genetics*
  • Transcriptome/genetics*
  • Zebrafish/genetics*
PubMed
27503353 Full text @ Adv. Genet.
Abstract
Zebrafish and medaka that develop tumors have become valuable tools for experimental cancer research. With the advent of microarrays and new sequencing technologies it has become feasible to perform whole genome, exome, and transcriptome analyses in these fish models. Analyses that compare the two fish models with each other and with data from human tumors have revealed a plethora of important insights. An unexpected high degree of comparability of molecular features of fish and human tumors has been detected. Furthermore, analyses of the fish model data have uncovered molecules that have not received appropriate attention in studies on their human tumor counterparts and thus have provided valuable candidates for novel biomarkers and therapeutic targets.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping