PUBLICATION
Genomic and Transcriptomic Approaches to Study Cancer in Small Aquarium Fish Models
- Authors
- Regneri, J., Klotz, B., Schartl, M.
- ID
- ZDB-PUB-160810-14
- Date
- 2016
- Source
- Advances in genetics 95: 31-63 (Chapter)
- Registered Authors
- Schartl, Manfred
- Keywords
- Array CGH, Cancer models, Deep-sequencing, Exome-sequencing, Genome-wide, Medaka, Microarray, RNA-seq, Xiphophorus, Zebrafish
- MeSH Terms
-
- Animals
- Gene Expression Profiling/methods
- Genomics/methods
- Humans
- Models, Animal
- Neoplasms/genetics*
- Transcriptome/genetics*
- Zebrafish/genetics*
- PubMed
- 27503353 Full text @ Adv. Genet.
Citation
Regneri, J., Klotz, B., Schartl, M. (2016) Genomic and Transcriptomic Approaches to Study Cancer in Small Aquarium Fish Models. Advances in genetics. 95:31-63.
Abstract
Zebrafish and medaka that develop tumors have become valuable tools for experimental cancer research. With the advent of microarrays and new sequencing technologies it has become feasible to perform whole genome, exome, and transcriptome analyses in these fish models. Analyses that compare the two fish models with each other and with data from human tumors have revealed a plethora of important insights. An unexpected high degree of comparability of molecular features of fish and human tumors has been detected. Furthermore, analyses of the fish model data have uncovered molecules that have not received appropriate attention in studies on their human tumor counterparts and thus have provided valuable candidates for novel biomarkers and therapeutic targets.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping