PUBLICATION
Construction of the Inbred Strain
- Authors
- Shinya, M.
- ID
- ZDB-PUB-160729-22
- Date
- 2016
- Source
- Methods in molecular biology (Clifton, N.J.) 1451: 107-18 (Chapter)
- Registered Authors
- Shinya, Minori
- Keywords
- Genetic homogeneity, Inbred strain, Inbreeding depression, Polymorphisms, Sib-pair mating, Zebrafish
- MeSH Terms
-
- Genetics, Population/methods*
- Inbreeding
- Polymorphism, Genetic/genetics*
- PubMed
- 27464804 Full text @ Meth. Mol. Biol.
Citation
Shinya, M. (2016) Construction of the Inbred Strain. Methods in molecular biology (Clifton, N.J.). 1451:107-18.
Abstract
Genetically homogeneous populations such as inbred strains are valuable experimental tools in various fields of biomedical analyses. In many animals, inbred strains are established by consecutive sib-pair mating for a minimum of 20 generations. As the generation proceeds, fitness of the population reduces usually. Therefore, in order to establish inbred strains, the important point is the selection of pairs in good condition at each generation. Here, I describe the procedure and tips for generating inbred strains in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping