PUBLICATION

Zebrafish Discoveries in Cancer Epigenetics

Authors
Chernyavskaya, Y., Kent, B., Sadler, K.C.
ID
ZDB-PUB-160512-24
Date
2016
Source
Advances in experimental medicine and biology   916: 169-97 (Chapter)
Registered Authors
Chernyavskaya, Yelena, Kent, Brandon, Sadler Edepli, Kirsten C.
Keywords
none
MeSH Terms
  • Acetylation
  • Animals
  • DNA Methylation
  • Disease Models, Animal*
  • Epigenesis, Genetic*
  • Neoplasms/genetics*
  • Phosphorylation
  • Zebrafish
PubMed
27165354 Full text @ Adv. Exp. Med. Biol.
Abstract
The cancer epigenome is fundamentally different than that of normal cells. How these differences arise in and contribute to carcinogenesis is not known, and studies using model organisms such as zebrafish provide an opportunity to address these important questions. Modifications of histones and DNA comprise the complex epigenome, and these influence chromatin structure, genome stability and gene expression, all of which are fundamental to the cellular changes that cause cancer. The cancer genome atlas covers the wide spectrum of genetic changes associated with nearly every cancer type, however, this catalog is currently uni-dimensional. As the pattern of epigenetic marks and chromatin structure in cancer cells is described and overlaid on the mutational landscape, the map of the cancer genome becomes multi-dimensional and highly complex. Two major questions remain in the field: (1) how the epigenome becomes repatterned in cancer and (2) which of these changes are cancer-causing. Zebrafish provide a tractable in vivo system to monitor the epigenome during transformation and to identify epigenetic drivers of cancer. In this chapter, we review principles of cancer epigenetics and discuss recent work using zebrafish whereby epigenetic modifiers were established as cancer driver genes, thus providing novel insights into the mechanisms of epigenetic reprogramming in cancer.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping