PUBLICATION

SignaFish: A Zebrafish-Specific Signaling Pathway Resource

Authors
Csályi, K., Fazekas, D., Kadlecsik, T., Türei, D., Gul, L., Horváth, B., Módos, D., Demeter, A., Pápai, N., Lenti, K., Csermely, P., Vellai, T., Korcsmáros, T., Varga, M.
ID
ZDB-PUB-160421-1
Date
2016
Source
Zebrafish   13(6): 541-544 (Journal)
Registered Authors
Varga, Máté
Keywords
none
MeSH Terms
  • Animals
  • Databases, Genetic*
  • Gene Regulatory Networks*
  • Internet
  • Signal Transduction*
  • Zebrafish/genetics*
PubMed
27097230 Full text @ Zebrafish
Abstract
Understanding living systems requires an in-depth knowledge of the signaling networks that drive cellular homeostasis, regulate intercellular communication, and contribute to cell fates during development. Several resources exist to provide high-throughput data sets or manually curated interaction information from human or invertebrate model organisms. We previously developed SignaLink, a uniformly curated, multi-layered signaling resource containing information for human and for the model organisms nematode Caenorhabditis elegans and fruit fly Drosophila melanogaster. Until now, the use of the SignaLink database for zebrafish pathway analysis was limited. To overcome this limitation, we created SignaFish ( http://signafish.org ), a fish-specific signaling resource, built using the concept of SignaLink. SignaFish contains more than 200 curation-based signaling interactions, 132 further interactions listed in other resources, and it also lists potential miRNA-based regulatory connections for seven major signaling pathways. From the SignaFish website, users can reach other web resources, such as ZFIN. SignaFish provides signaling or signaling-related interactions that can be examined for each gene or downloaded for each signaling pathway. We believe that the SignaFish resource will serve as a novel navigating point for experimental design and evaluation for the zebrafish community and for researchers focusing on nonmodel fish species, such as cyclids.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping