PUBLICATION

Inflammatory cytokines provide both infection-responsive and developmental signals for blood development: Lessons from the zebrafish

Authors
Hall, C., Crosier, P., Crosier, K.
ID
ZDB-PUB-151114-5
Date
2016
Source
Molecular immunology   69: 113-22 (Review)
Registered Authors
Crosier, Kathy, Crosier, Phil, Hall, Chris
Keywords
Cytokines, Demand-driven hematopoiesis, Hematopoiesis, Infection, Inflammation, Zebrafish
MeSH Terms
  • Animals
  • Cytokines/immunology
  • Hematopoiesis/immunology*
  • Hematopoietic Stem Cells/cytology*
  • Infections/immunology*
  • Inflammation/immunology
  • Zebrafish/embryology*
  • Zebrafish/immunology*
PubMed
26563946 Full text @ Mol. Immunol.
Abstract
Hematopoietic stem cells (HSCs) are rare, largely dormant, long-lived cells that are capable of establishing and regenerating all mature blood cell lineages throughout the life of the host. Given their therapeutic importance, understanding factors that regulate HSC development and influence HSC proliferation and differentiation is of great interest. Exploring HSC biology through the lens of infection has altered our traditional view of the HSC. The HSC can now be considered a component of the immune response to infection. In response to inflammatory cytokine signaling, HSCs enhance their proliferative state and contribute to the production of in-demand blood cell lineages. Similar cytokine signaling pathways also participate during embryonic HSC production. With its highly conserved hematopoietic system and experimental tractability, the zebrafish model has made significant contributions to the hematopoietic field. In particular, the zebrafish system has been ideally suited to help reveal the molecular and cellular mechanisms underlying HSC development. This review highlights recent zebrafish studies that have uncovered new mechanistic insights into how inflammatory signaling pathways influence HSC behavior during infection and HSC production within the embryo.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping