PUBLICATION
Zebrafish germ cells: motility and guided migration
- Authors
- Paksa, A., Raz, E.
- ID
- ZDB-PUB-150804-9
- Date
- 2015
- Source
- Current opinion in cell biology 36: 80-85 (Review)
- Registered Authors
- Paksa, Azadeh, Raz, Erez
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Movement*
- Germ Cells/cytology*
- Morphogenesis
- Zebrafish*/embryology
- PubMed
- 26232877 Full text @ Curr. Opin. Cell Biol.
Citation
Paksa, A., Raz, E. (2015) Zebrafish germ cells: motility and guided migration. Current opinion in cell biology. 36:80-85.
Abstract
In the course of embryonic development, the process of cell migration is critical for establishment of the embryonic body plan, for morphogenesis and for organ function. Investigating the molecular mechanisms underlying cell migration is thus crucial for understanding developmental processes and clinical conditions resulting from abnormal cell migration such as cancer metastasis. The long-range migration of primordial germ cells toward the region at which the gonad develops occurs in embryos of various species and thus constitutes a useful in vivo model for single-cell migration. Recent studies employing zebrafish embryos have greatly contributed to the understanding of the mechanisms facilitating the migration of these cells en route to their target.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping