PUBLICATION
The melanocyte lineage in development and disease
- Authors
- Mort, R.L., Jackson, I.J., Patton, E.E.
- ID
- ZDB-PUB-150212-5
- Date
- 2015
- Source
- Development (Cambridge, England) 142: 620-632 (Review)
- Registered Authors
- Patton, E. Elizabeth
- Keywords
- MITF, Melanoma, Neural crest, Stem cells
- MeSH Terms
-
- Animals
- Humans
- Melanocytes/cytology*
- Melanocytes/metabolism*
- Melanoma/metabolism
- Melanoma/pathology
- Microphthalmia-Associated Transcription Factor/metabolism
- Neural Crest/cytology
- Stem Cells/cytology
- Stem Cells/metabolism
- PubMed
- 25670789 Full text @ Development
Citation
Mort, R.L., Jackson, I.J., Patton, E.E. (2015) The melanocyte lineage in development and disease. Development (Cambridge, England). 142:620-632.
Abstract
Melanocyte development provides an excellent model for studying more complex developmental processes. Melanocytes have an apparently simple aetiology, differentiating from the neural crest and migrating through the developing embryo to specific locations within the skin and hair follicles, and to other sites in the body. The study of pigmentation mutations in the mouse provided the initial key to identifying the genes and proteins involved in melanocyte development. In addition, work on chicken has provided important embryological and molecular insights, whereas studies in zebrafish have allowed live imaging as well as genetic and transgenic approaches. This cross-species approach is powerful and, as we review here, has resulted in a detailed understanding of melanocyte development and differentiation, melanocyte stem cells and the role of the melanocyte lineage in diseases such as melanoma.
Errata / Notes
This article is corrected by ZDB-PUB-220906-13.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping