PUBLICATION

"Interactions of the orexin/hypocretin neurons and the histaminergic system"

Authors
Sundvik, M., Panula, P.
ID
ZDB-PUB-141209-11
Date
2015
Source
Acta physiologica (Oxford, England)   213(2): 321-33 (Review)
Registered Authors
Panula, Pertti, Sundvik, Maria
Keywords
Autoimmune, Histamine, hypocretin/orexin, mouse, narcolepsy, zebrafish
MeSH Terms
  • Animals
  • Brain/metabolism*
  • Brain/physiopathology
  • Histamine/metabolism*
  • Humans
  • Intracellular Signaling Peptides and Proteins/metabolism*
  • Narcolepsy/metabolism*
  • Narcolepsy/physiopathology
  • Neurons/metabolism*
  • Neuropeptides/metabolism*
  • Orexins
  • Wakefulness/physiology
PubMed
25484194 Full text @ Acta Physiol. (Oxf).
Abstract
Histaminergic and orexin/hypocretin systems are components in the brain wake promoting system. Both are affected in the sleep disorder narcolepsy, but the role of histamine in narcolepsy is unclear. The histaminergic neurons are activated by the orexin/hypocretin system in rodents, and the development of the orexin/hypocretin neurons is bidirectionally regulated by the histaminergic system in zebrafish. This review summarizes the current knowledge of the interactions of these two systems in normal and pathological conditions in humans and different animal models. This article is protected by copyright. All rights reserved.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping