PUBLICATION
There and back again: development and regeneration of the zebrafish lateral line system
- Authors
- Thomas, E.D., Cruz, I.A., Hailey, D.W., Raible, D.W.
- ID
- ZDB-PUB-141022-10
- Date
- 2015
- Source
- Wiley interdisciplinary reviews. Developmental biology 4(1): 1-16 (Review)
- Registered Authors
- Raible, David
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Movement/physiology
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/embryology
- Hair Cells, Auditory/physiology
- Lateral Line System/embryology
- Lateral Line System/growth & development
- Lateral Line System/physiology*
- Models, Biological
- Regeneration/physiology*
- Signal Transduction/physiology*
- Zebrafish/embryology
- Zebrafish/growth & development
- Zebrafish/physiology*
- PubMed
- 25330982 Full text @ Wiley Interdiscip Rev Dev Biol
Citation
Thomas, E.D., Cruz, I.A., Hailey, D.W., Raible, D.W. (2015) There and back again: development and regeneration of the zebrafish lateral line system. Wiley interdisciplinary reviews. Developmental biology. 4(1):1-16.
Abstract
The zebrafish lateral line is a sensory system used to detect changes in water flow. It is comprised of clusters of mechanosensory hair cells called neuromasts. The lateral line is initially established by a migratory group of cells, called a primordium, that deposits neuromasts at stereotyped locations along the surface of the fish. Wnt, FGF, and Notch signaling are all important regulators of various aspects of lateral line development, from primordium migration to hair cell specification. As zebrafish age, the organization of the lateral line becomes more complex in order to accommodate the fish's increased size. This expansion is regulated by many of the same factors involved in the initial development. Furthermore, unlike mammalian hair cells, lateral line hair cells have the capacity to regenerate after damage. New hair cells arise from the proliferation and differentiation of surrounding support cells, and the molecular and cellular pathways regulating this are beginning to be elucidated. All in all, the zebrafish lateral line has proven to be an excellent model in which to study a diverse array of processes, including collective cell migration, cell polarity, cell fate, and regeneration. For further resources related to this article, please visit the WIREs website. Conflict of interest: The authors have declared no conflicts of interest for this article.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping