PUBLICATION

Zebrafish as a model for zoonotic aquatic pathogens

Authors
Rowe, H.M., Withey, J.H., Neely, M.N.
ID
ZDB-PUB-140513-394
Date
2014
Source
Developmental and comparative immunology   46(1): 96-107 (Journal)
Registered Authors
Neely, Melody N.
Keywords
Aquaculture, Aquatic pathogens, Bacteria, Environmental reservoir, Zebrafish, Zoonotic
MeSH Terms
  • Animals
  • Bacteria/classification
  • Bacteria/immunology
  • Bacterial Infections/immunology*
  • Bacterial Physiological Phenomena
  • Host-Pathogen Interactions
  • Humans
  • Water Microbiology*
  • Zebrafish/microbiology*
PubMed
24607289 Full text @ Dev. Comp. Immunol.
Abstract
Aquatic habitats harbor a multitude of bacterial species. Many of these bacteria can act as pathogens to aquatic species and/or non-aquatic organisms, including humans, that come into contact with contaminated water sources or colonized aquatic organisms. In many instances, the bacteria are not pathogenic to the aquatic species they colonize and are only considered pathogens when they come into contact with humans. There is a general lack of knowledge about how the environmental lifestyle of these pathogens allows them to persist, replicate and produce the necessary pathogenic mechanisms to successfully transmit to the human host and cause disease. Recently, the zebrafish infectious disease model has emerged as an ideal system for examining aquatic pathogens, both in the aquatic environment and during infection of the human host. This review will focus on how the zebrafish has been used successfully to analyze the pathogenesis of aquatic bacterial pathogens.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping