PUBLICATION

Zebrafish models of cerebrovascular disease

Authors
Walcott, B.P., and Peterson, R.T.
ID
ZDB-PUB-140502-5
Date
2014
Source
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism   34(4): 571-577 (Review)
Registered Authors
Peterson, Randall
Keywords
none
MeSH Terms
  • Animals
  • Cerebrovascular Disorders/drug therapy*
  • Cerebrovascular Disorders/pathology
  • Disease Models, Animal*
  • Drug Discovery/methods*
  • Zebrafish*/genetics
  • Zebrafish*/metabolism
PubMed
24517974 Full text @ J. Cereb. Blood Flow Metab.
Abstract

Perturbations in cerebral blood flow and abnormalities in blood vessel structure are the hallmarks of cerebrovascular disease. While there are many genetic and environmental factors that affect these entities through a heterogeneous group of disease processes, the ultimate final pathologic insult in humans is defined as a stroke, or damage to brain parenchyma. In the case of ischemic stroke, blood fails to reach its target destination whereas in hemorrhagic stroke, extravasation of blood occurs outside of the blood vessel lumen, resulting in direct damage to brain parenchyma. As these acute events can be neurologically devastating, if not fatal, development of novel therapeutics are urgently needed. The zebrafish (Danio rerio) is an attractive model for the study of cerebrovascular disease because of its morphological and physiological similarity to human cerebral vasculature, its ability to be genetically manipulated, and its fecundity allowing for large-scale, phenotype-based screens.

Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping